New publication in AIDS on antiretroviral combination use during pregnancy and the risk of major congenital malformations.
Anick Bérard, PhD and her colleagues conducted a cohort study using the Quebec Pregnancy Cohort. The results of the study show that antiretroviral therapy during the first trimester of pregnancy was not associated with the risk of overall major congenital malformations (MCMs) but may be associated with an increased risk of defects of the small intestine. However, HIV-positive pregnant women who are not treated with antiretrovirals during pregnancy seem to have a higher risk of malformations; this is not seen among those who are treated, which could indicate that the underlying condition puts women at risk and not the treatment.To read the abstract click here.
New publication in Paediatric Perinatal Epidemiology on antidepressants use during pregnancy and the risk of ADHD.
In this publication, Takoua Boukhris, PhD candidate and his colleagues conducted a cohort study using the large population-based prospective cohort of pregnant women the Quebec Pregnancy Cohort. The results of the study suggests that antidepressants use during the 2nd and 3rd trimester of pregnancy, specifically tricyclics, is an independent risk factor for ADHD in children above and beyond the risk associated with maternal depression/anxiety or ADHD. However, residual confounding by indication severity could not be completely ruled out. To read the abstract click here.
New publication in "British Journal of Clinical Pharmacology" on the use of antibiotics during pregnancy and the risk of MCM
In this publication, Flory Tsobo, M.D.,PhD candidate and his colleagues conducted a cohort study using the Quebec Pregnancy Cohort. A large prospective cohort of pregnant women in Quebec. The results of the study show that clindamycin, doxycycline, quinolones, macrolides and phenoxymethylpenicillin in utero exposure were linked to organ-specific malformations. Amoxicillin, cephalosporins and nitrofurantoin were not associated with MCMs. To read the abstract click here.
New publication in Obstetric & Gynecology on Neurodevelopmental outcomes after Assisted Reprocuctive Technologies (ART)
Jacques Balayla, M.D., and his colleagues conducted a study using the prospective cohort 3D-Study. The results of the study show that children born after ART had similar cognitive, motor and language development as children born after natural conception at 2 years of age. Les résultats montrent que les enfants nés suite à des traitements de fertilité ont un développement cognitif, moteur et langagier semblablent à celui des enfants nés de conception naturelle. To read the abstract click here or to see the editor podcast. Media coverage: Physician's Briefing, Fox News Health; babycenter blog.