Does Risk of Embryonic Malformations Outweigh Benefits of Using SSRIs in Pregnant Women with Depression?
In a comprehensive new review article Dr Anick Bérard et al. present the most current understanding of the role selective serotonin reuptake inhibitors (SSRIs) play in increased risk of multiple diverse gestational malformations and take aim at the ongoing debate over whether SSRIs as a drug class can cause these malformations. The article, which also highlights the importance of serotonin - a key mediator of bioelectric control mechanisms - in normal embryonic development, is published in the preview issue of Bioelectricity. Click here
New publication in AIDS on antiretroviral combination use during pregnancy and the risk of major congenital malformations.
Anick Bérard, PhD and her colleagues conducted a cohort study using the Quebec Pregnancy Cohort. The results of the study show that antiretroviral therapy during the first trimester of pregnancy was not associated with the risk of overall major congenital malformations (MCMs) but may be associated with an increased risk of defects of the small intestine. However, HIV-positive pregnant women who are not treated with antiretrovirals during pregnancy seem to have a higher risk of malformations; this is not seen among those who are treated, which could indicate that the underlying condition puts women at risk and not the treatment.To read the abstract click here.
New publication in Paediatric Perinatal Epidemiology on antidepressants use during pregnancy and the risk of ADHD.
In this publication, Takoua Boukhris, PhD candidate and his colleagues conducted a cohort study using the large population-based prospective cohort of pregnant women the Quebec Pregnancy Cohort. The results of the study suggests that antidepressants use during the 2nd and 3rd trimester of pregnancy, specifically tricyclics, is an independent risk factor for ADHD in children above and beyond the risk associated with maternal depression/anxiety or ADHD. However, residual confounding by indication severity could not be completely ruled out. To read the abstract click here.
New publication in "British Journal of Clinical Pharmacology" on the use of antibiotics during pregnancy and the risk of MCM
In this publication, Flory Tsobo, M.D.,PhD candidate and his colleagues conducted a cohort study using the Quebec Pregnancy Cohort. A large prospective cohort of pregnant women in Quebec. The results of the study show that clindamycin, doxycycline, quinolones, macrolides and phenoxymethylpenicillin in utero exposure were linked to organ-specific malformations. Amoxicillin, cephalosporins and nitrofurantoin were not associated with MCMs. To read the abstract click here.