Cohorts and data sources
North American field study on antidepressants: Mother's health and development of the child.
In order to conduct epidemiological studies on antidepressant use in the perinatal period and cognitive and behavioural development of the child, a multicentre study is currently underway to recruit a prospective cohort with one group of 300 pregnant women using antidepressants at the time of pregnancy diagnosis and another group of 100 women taking no antidepressants during pregnancy.
Pregnant women are recruited when their health professional or the woman herself calls one of the major North American teratogen information services:
a) IMAGe Center, CHU de Sainte-Justine, Montreal, Canada
b) Motherisk, Hospital for Sick Children (Sick Kids), Toronto, Canada
c) Organization of Teratology Information Specialists (OTIS), USA
Information is collected on the severity of depression and anxiety, as well as on lifestyle, perinatal complications, health care system utilization, quality of life, pre- and postpartum maternal stress, and maternal attachment, using telephone interviews during each trimester of pregnancy as well as at 2, 12, 24 and 36 months postpartum. Furthermore, children are evaluated at home by a cognitive development specialist at 12, 24 and 36 months of age.
Ethics approval was obtained from the CHU Sainte-Justine, Sick Kids Hospital, and Children's Hospital of Western Ontario ethics committees.
Canadian Institutes of Health Research (CIHR), Fonds de la recherche en santé du Québec (FRSQ), and Conseil du médicament.